The hepatoprotective potentials of the Holostemma annulare ehanolic extract were investigated. The fraction were prepared and tested against carbon tetrachloride induced and Paracetamol induced liver damage in experimental rats. changes in the biochemical markers like Aspartate aminotransferase(AST), Alanine aminotransferase(ALT), Alkaline phosphatase (ALP) and bilirubin were determined in both treated and control groups. The effects of the extracts were compared with that of sylimarin (100 mg/kg) treated group.Phytochemical investigations showed the presence of alkaloids, flavonoids, terpenods, saponins and absence of glycosides, the results suggest that CCl4 and Paracetamol (2g/kg) elevated the levels of AST,ALT,ALP.and bilirubin. Treatment of different doses (100mg/kg, 150mg/kg and 250mg/kg) of Holostemma annulare extract ameliorated the effects of the hepatotoxins and significantly (p<0.05) reduced elevated levels of biochemical marker enzyme.
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